BMB/MICRB 251:MOLECULAR AND CELLBIOLOGY I

Fall 2006 - Mon Wed Fri 12:20-1:10, 26 Hosler
 

Dr. Frank Pugh (lec 1-21)

Dr. David Gilmour (lec 22-42)

office: 452 N. Frear

office: 403 S. Frear

phone: 863-8252

phone: 863-8905

email: bfp2@psu.edu

email: dsg11@psu.edu

office hours: Mon.1:30-3:30 or by appointment

office hours: Mon.1:30-3:30 or by appointment

TA:  Lindsay Dutko, lmd294@psu.edu, office hours Tues. 2-4 pm, 124 Life Sciences Bldg.

Notes for lectures 1-20 (PDF)
 

lec

date

TOPIC

READING: chpt(pgs)

Dr. Frank Pugh's lectures

1

Sept 6

 Universal features of cells

 1

2

Sept 8

 Chemistry of the cell

 2

3

Sept 11

 Protein structure

 3

4

Sept 13

 Proteins as enzymes

 3

5

Sept 15

 Chromosome structure

 4

6

Sept 18

 DNA replication mechanisms

 5

7

Sept 20

 Initiation of DNA replication

 5

8

Sept 22

 DNA repair

 5

9

Sept 25

 DNA recombination

 5

Review session, September 26, 8:00 PM, place to be announced

10

Sept 27

Exam1

 Chapters1-5

11

Sept 29

 Transcription

 6

12

Oct 2

 RNA processing

 6

13

Oct 4

 Translation

 6

 

Oct 6

No Class, Study Day! J

 

14

Oct 9

 Gene regulatory proteins

 7

15

Oct 11

 Gene regulatory pathways

 7

16

Oct 13

 Post transcriptional regulation

 7

17

Oct 16

 Biochemical methods

 8

18

Oct 18

 Molecular biology methods

 8

19

Oct 20

 Protein structure/function methods

 8

20

Oct 23

 Genetic & genomic methods

 8

Review session, October 24, 8:00 PM, place to be announced

21

Oct 25

Exam2

 Chapters 6-8

Dr. David Gilmour's lectures

22

Oct 27

Visualizing cells

  9

23

Oct 30

Membrane structure and the lipid bilayer

 10

24

Nov 1

Membrane proteins

 10

25

Nov 3

Membrane proteins

 10

26

Nov 6

Membrane transport - carrier proteins and channels

 11

27

Nov 8

Channels and the membrane potential

 11

28

Nov 10

Nerve function

 11

29

Nov 13

Intracellular compartments and protein sorting

 12

30

Nov 15

Nuclear transport

 12

31

Nov 17

Mitochondrial, chloroplast, peroxisome import

 12

Review session, November 19, 7:00 PM

32

Nov 20

Exam 3

  Covers Lec 22-31

33

Nov 21

Endoplasmic reticulum, cotranslational transport

 12

 

Nov 22

NO CLASS - Thanksgiving

 

 

Nov 24

NO CLASS - Thanksgiving

 

34

Nov 27

Endoplasmic reticulum, vesicular transport

 13

35

Nov 29

ER to golgi to endosome to lysosome

 13

36

Dec 1

Endocytosis

 13

37

Dec 4

Exocytosis

 13

38

Dec 6

Energetics and energy conversion

  2

39

Dec 8

Mitochondria

 14

40

Dec 11

Mitochondria

 14

41

Dec 13

Chloroplast

 14

42

Dec 15

Chloroplast

 14

Review session, December 17, 7:00 PM

43

Exam week

Exam 4, time and place to be determined.
The exam will be 50 minutes.

 Covers Lec 33-42

Required textbook: Alberts, et al., Molecular Biology of the Cell,fourth edition. You should complete the reading assignment before class so that you are familiar with the lecture material.  This should aid you in following each lecture.

Lecture notes: Overhead notes that are used in lectures and any figures not in the Alberts text will be posted before class. You are strongly encouraged to bring these lecture notes to class.  Links to the notes that have been posted are made by clicking on the lecture number in the schedule posted above.

Exams: Each exam will consist of 33 multiple choice questions worth 3 points each.  You will be asked to present your student I.D. when you submit your exams.  Scores will be reported by email to your student account directly from University Testing Services.

Exam scores: As soon as the exams have been processed by University Testing Services, your score will be reported by email to your student access account. It is your responsibility to learn to use your account and to check your posted scores for accuracy. Take your student ID card to a CAC Help desk (215 Computer Building; 12 Willard) to learn how to use your account. Call 863-2494 or 863-1035 for more information.

Grades: The following table gives approximate assignments for final grades. This scale is based on an overall class mean of 75% or higher. If the class mean is lower, the scale will be adjusted downward. It will not be adjusted upward. So for example, if you earn a 90% or higher you are guaranteed an A or A-.
 

GRADE:

PERCENTAGE:

A and A-

90%-100%

B+, B and B-

75%-90%

C+ and C

60%-75%

D

50%-60%

F

lower than 50%

Missed exams: Make up exams are either all essay questions or a mixture of essay and short answer questions (instructor's discretion) and must be taken prior to the next exam, or you will receive a zero. When ever possible, notify the instructor prior to the exam. Exams should only be missed for a family emergency, accident, or serious illness, so written documentation of the excuse is required. 

No extra credit work will be accepted. No exams will be dropped.

Academic integrity: The students and instructors are bound by the rules and procedures on academic integrity set by the Eberly College of Science Academic Integrity Committee. A complete listing of these policies can be found at the following web site: http://www.science.psu.edu/academic/Integrity/index.html.

It is the student's responsibility to know and abide by these policies. Failure to do so may result in sanctions or expulsion.