A postdoctoral position is available to determine the structures of eukyarotic gene regulatory complexes including histone acetyltransferase complexes on their own or bound to nucleosomes. Crystals are available for some projects, while crystallization conditions need to be determined or optimized for others.

The Tan laboratory is fully equipped for biochemical, crystallization and crystallography work. Our efforts are also enhanced by techniques to reconstitute multicomponent complexes (Nature Struct. Biol., 8:695, 2001, Prot. Expr. Purif., 40:385, 2005, MCB, 25:5535, 2005) and crystallization design ideas developed during successful structural determination of the yeast TFIIA/TBP/DNA and MATalpha2/MCM1/DNA ternary complexes (Nature, 381:127, 1996; Nature, 391:660, 1998; JMB 297:947, 2000).

The Center for Gene Regulation at Penn State University is a dynamic and highly collaborative environment which includes the groups of Drs. David Gilmour, Frank Pugh, Joe Reese, Yanming Wang and Song Tan, each with research programs targeted at understanding the molecular basis for transcriptional regulation.

Crystallographers and molecular biologists/biochemists who would like to learn crystallography are encouraged to apply. Prior experience with macromolecular crystallography and protein expression/purification is preferred but not essential. Please send curriculum vitae and the names of three references to:

Dr. Song Tan
Center for Gene Regulation
Dept. of Biochemistry and Molecular Biology
Box 108-W, Althouse Laboratory
Penn State University
University Park, PA 16802

Email: sxt30@psu.edu, Phone: 814-865-3355, Fax: 814-863-7024