Undergraduate Research: Biochemical Characterization of Steroid Hormone Receptors in Subavian Species
Boston University 1984-1988
Advisor: Ian P. Callard

  Dr. Callard's web site

1. Riley D., Reese J.C. and Callard I.P. (1988). Hepatic Progesterone Receptors: Characterization in the Turtle Chrysemys picta. Endocrinology 123:1195-1201.

2. Callard I.P., Klosterman L.L., Sobera L.A., Fileti L.A. and Reese J.C. (1989). Endocrine Regulation in Elasmobranchs: Archetype of Terrestrial Vertebrates. In: Evolutionary and Contemporary Biology of Elasmobranchs (Ed. W.C. Hamlett). J. Experimental Zoology Suppl. 2:12-17.

3. Reese J.C. and Callard I.P. (1989). Two Progesterone Receptors in the Oviduct of the Freshwater Turtle Chrysemys picta: Possible Homology to Mammalian and Avian PR Systems. J. Steroid Biochemistry. 33:297-310.

4. Reese J.C and Callard I.P. (1991). Characterization of a Specific Estrogen Receptor in the Oviduct of the Little Skate, Raja erinacea. General and Comparative Endocrinology 84:170-181.
 
 

Graduate Research: Molecular Characterization of Estrogen Receptor Agonists and Antagonists
University of Illinois, Urbana IL 1988-1992
Advisor: Benita S. Katzenellenbogen

 Dr. Katzenellenbogen's web site

5. Reese J.C. and Katzenellenbogen B.S. (1991). Mutagenesis of Cysteines in the Hormone Binding Domain of the Human Estrogen Receptor: Alterations in Binding and Transcriptional Activation by Covalently and Reversibly Attaching Ligands. J. Biological Chemistry 266:10880-10887.

6. Reese J.C. and Katzenellenbogen B.S. (1991). Differential DNA-Binding Abilities of Estrogen Receptor Occupied by Two Classes of Antiestrogens: Studies using Receptor Overexpressed in Mammalian Cells. Nucleic Acids Research 19:6595-6602.

7. Reese J.C. and Katzenellenbogen B.S. (1992). Characterization of a Temperature-Sensitive Mutation in the Hormone-Binding Domain of the Human Estrogen Receptor: Studies in Cell Extracts and Intact Cells and Their Implications for Hormone-Dependent Transcriptional Activity. J. Biological Chemistry. 267:9868-9873.

8. Reese  J.C. and Katzenellenbogen B.S. (1992). Examination of the DNA-Binding Ability of Estrogen Receptor in Whole Cells: Implications for Hormone-Independent Transactivation and the Actions of Antiestrogens. Molecular and Cellular Biology. 12:4531-4538.

9. Reese J.C., Wooge C.H. and Katzenellenbogen B.S. (1992). Identification of Two Cysteines Closely Positioned in the Ligand-Binding Pocket of the Human Estrogen Receptor: Roles in Ligand Binding and Transcriptional Activation. Molecular Endocrinology 6:2160-2166.

10. Pakdel F., Reese J.C. and Katzenellenbogen B.S. (1993). Identification of Charged Residues in the Hormone Binding Domain of the Human Estrogen Receptor Implicated in Transcriptional Activity of the Receptor. Molecular Endocrinology. 7:1408-1413.

11. Reese J.C. and Katzenellenbogen B.S. (1993). Ligand Requirements for Estrogen Receptor Function and the Actions of Antiestrogens. In: Steroid Hormone Receptors: Basic and Clinical Aspects. ed. V.K. Moudgil, Birkhauser, Boston.

12. Katzenellenbogen B.S.,  Fang H., Ince B.A., Pakdel F., Reese J.C., Wooge C.H. and Wrenn C.K. (1993). Estrogen Receptors: Ligand Discrimination and Antiestrogen Action. Breast Cancer Research and Treatment 27:17-26.

13.  Katzenellenbogen B.S.,  Bhardwaj B., Fang H., Ince B.A., Pakdel F., Reese J.C., Schodin D. and Wrenn C.K. (1993). Hormone Binding and Transcription Activation by Estrogen Receptors: Analyses Using Mammalian and Yeast Systems. J. Steroid Biochem. & Molecular Biology 47:39-40.
 
 

Postdoctoral Training: Molecular and Genetic Characterization of the Yeast TBP Associated Facors
Postdoctoral Fellow of the Damon Runyon-Walter Winchell Cancer Research Fund.  1993-1997
Mentor: Michael Green, HHMI and Program in Molecular Medicine, University of Massachusetts Medical Center

 Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation

 Dr Green's web site
 

14. Reese J.C., Apone L., Walker S.W., Griffin, L.A. and Green, M.R. (1994). Yeast TAFIIs in a Multisubunit Complex Required for Activated Transcription. Nature371: 523-527.

15. Apone L.M., Virbasius C.A., Reese J.C. and Green M.R. (1996). Yeast TAFII90 is Required for Cell Cycle Progression Through G2/M but Not General Transcription Activation. Genes and Development 10:2368-2380.

16. Walker S.S., Reese J.C., Apone L.M. and Green M.R. (1996). Transcription Activation in Cells Lacking TAFIIs. Nature 383:185-188.

17. Gadbois E.L., Chao D.M., Reese J.C., Green M.R. and Young R.A. (1996). Functional Antagonism Between RNA Polymerase II Holoenzyme and Global Negative Regulator NC2 In Vivo.  Proc. Natl. Acad. Sci. U.S.A.  94:3145-3150.

18. Walker S.S.,  Shen, W.-C., Reese, J.C.  Apone, L. and Green, M.R. (1997) Yeast TAF145 Required for Transcription of G1/S Cyclin Genes and Regulated by the Cellular Growth State. Cell 90:607-614.

Patents

1. Novel fungal multisubunit protein complex critical for expression of fungal proteins
#5,847,077 United States-granted 12/8/98
#EP0782620 European Patent Office-granted 9/7/97
 

Assistant Professor, Department of Biochemistry and Molecular Biology Penn State University
1997-2003
Associate Professor, Department of Biochemistry and Molecular Biology Penn State University
2003-present

Established Investigator of the American heart Association (2002-2006)

 American Heart Association
 

19. Grant P.A., Schieltz D., Pray-Grant M.G., Steger D.J., Reese J.C., Yates J., Workman J.L. (1998) A Subset of TAF_IIs Are Integral Components of the SAGA Complex Required for Nucleosome Acetylation and Transcriptional Stimulation Cell 94: 45-53.

20. Reese, J.C., Zhang, Z., and Kurpad, H. (2000) Identification of a novel TFIID subunit, TSG2/TAF48. J. Biological Chemistry275:17391-17398.

21. Li, B. and Reese, J.C. (2000) Derepression of DNA Damage-Regulated Genes requires Yeast TBP-Associated Factors. EMBO J 19:4091-4100.

22. Stitzel, M.L., Durso, R. and Reese, J.C. (2001)The Proteasome Regulates the UV-induced Activation of the AP-1 Like Transcription Factor Gcn4. Genes and Development15 128-133.

23. Reese, J.C. and Green, M.R. (2001). Genetic analysis of TAF68/61reveals links to cell cycle regulators. Yeast 18:1197-1205.

24. Li, B. and Reese, J.C. (2001). Ssn6-Tup1 Regulates RNR3 by Positioning Nucleosomes and Affecting the Chromatin Structure at the Upstream repression Sequences. J. Biological Chemistry 276:33788-97.

25. Hassan, A.H., Neely, K.E., Vignali, M., Reese, J.C. ans Workman, J.L. (2001). Promoter targeting of Chromatin-modifying complexes. Frontiers in Biosciences, 6:D1054-1064

26. Durso, R.J., Fisher, A. K., Albright-Frey, T.J. and Reese, J.C. (2001). Analysis of TAF90 Mutants Displaying Allele-Specific and Global Defects in Transcription. Molecular and Cellular Biology, 21:7331-7344.

27. Kulesza, C.A., Van Buskirk, H.A. Cole, M.D., Reese, J.C., Smith, M.M. and Engel, D.A. (2002). Adenovirus E1A function requires the SAGA histone acetyltransferase complex. Oncogene, 21:1411-22.

28. Sharma, V.M,  Li, B. and Reese, J.C. (2003). SWI/SNF-dependent chromatin remodeling of RNR3 requires TAFIIs and the general transcription machinery. Genes and Development 17:502-515.

29. Reese, J.C. (2003). Basal Transcription Factors. Curr. Opin. Genetics Dev. 13:114-118.

30. Reese, J.C. and M.R. Green (2003). Functional Analysis of TFIID Components using Conditional Mutants. Methods in Enzymology 370:415-430.

31. Bergkessel, M. and Reese, J.C  (2004). The Yeast ortholog of proto-oncogene p54/RCK regulates G1/S checkpoint recovery by a novel mechanism, Genetics, 167:21-33.

32. Zhang, Z. and Reese, J.C. (2004). Ssn6-Tup1 requires the ISW2 Complex to position nucleosomes in Saccharomyces cerevisiae. EMBO J. 23:2246-2257.

33. Zhang, Z. and Reese, J.C. (2004). "Redundant mechanisms are used by Ssn6-Tup1 in repressing chromosomal gene transcription in saccharomyces cerevisiae" J. Biological Chemistry, 279:39240-39250.

34. Zhang, Z and Reese, J.C. (2005). Molecular genetic analysis of the Yeast Repressor Rfx1/Crt1 reveals a novel two-step regulatory mechanism. Molecular and Cellular Biology 25, 7399-411.

35. Ercan, S., Reese, J.C., Workman ,J.L. and  Simpson, R.T. (2005). Yeast recombination enhancer is stimulated by transcription activation. Molecular and  Cellular Biology 25, 7976-7987.

36. Zhang, Z, Li, B and Reese J. C.  (2006). Isolation of Yeast Nuclei and Micrococcal Nuclease Mapping of Nucleosome Positioning. Methods Mol Biol. 313, 245-56. (invited contribution)

37. Sharma, V.M., Tomar, R.S., Dempsey, A.E. and Reese, J.C. (2007). Histone deacetylases RPD3 and HOS2 regulate transcriptional activation of DNA damage inducible genes. Molecular and Cellular Biology 27, 3199-3210.

38.  Zhang, H. and Reese, J.C. (2007) Exposing the core promoter is sufficient to activate transcription and alter coactivator requirement at RNR3. Proc. Natl. Acad. Sci. U.S.A., 104, 8833-8838.

39. Reese, J.C., Zhang, H, Zhang, Z. (2008) Isolation of highly purified yeast nuclei for probing chromatin structure. Methods  Mol. Biol.  in press (invited contribution)

40. Tomar, R.S., Zhang, S., Brunkre-Reese, D.L., Wolcott, H.N.  and Reese, J.C. (2008) Yeast Rap1 regulates genomic integrity by activating DNA damage repair genes.  EMBO J. , in press.