The Keiler Lab at Penn State
What we do:
Our mission is to understand how proteins are selectively produced at the right time and in the right place to execute complex biological processes such as cell cycle progression and cellular differentiation. In particular, we are studying how protein translation and degradation are regulated by the tmRNA protein-tagging system, and how proteins are localized within the bacterial cell. We are also exploiting what we have learned about these fundamental processes to develop reagents that control bacterial development and proliferation, to be used for novel antibiotics and for basic scientific research.
Recent Publications (all publications are listed here)
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Russell JH and Keiler KC (2008) “Screen for localized proteins in Caulobacter crescentus.” PLoS ONE 3: e1756. link -
Russell JH and Keiler KC (2007) “Peptide signals encode protein localization.” J Bacteriol 189: 7581-5. pdf
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Hong S-J et al. (2007) “Proteomic identification of tmRNA substrates.” PNAS 104: 17128-33. pdf
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Cheng L et al. (2007) “Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease.” Protein Sci 16:1535-42. pdf
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Keiler KC (2007) “Physiology of tmRNA: what gets tagged and why?” Curr Opin Microbiol 10:169-75. pdf
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Lessner FH et al. (2007) “Proteolytic adaptor for tmRNA-tagged proteins from α-proteobacteria.” J Bacteriol 189:272-5. pdf
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Hong S-J et al. (2005) “Cell-cycle regulated degradation of tmRNA is controlled by RNase R and SmpB.” Mol Microbiol 57:565-75. pdf
Funding
NIH - NIGMS R01 68720 “Role of tmRNA in Development of Caulobacter crescentus.”
DTRA - W911NF0610144 “Selection of tmRNA inhibitors as antibacterial and plasmid elimination agents.”
We currently have positions for qualified scientists at all levels - more information is here.
401 Althouse Lab • University Park, PA 16802 • (814) 863-0801
