Dr. Sypes is not currently maintaining this site.
The information here is from Dr. Hardison's 2002 class.


Biochemistry & Molecular Biology 400
Course Information
            Pdfs of presentations
1_5_recdna_2mod.pdf
1_7,8,9_genome_mod.pdf
Part One: Genes, genomes Part Two: Replication, Repair, Rec., Tnpn Part Three: Pathway of Gene Expression Part Four: Regulation of Gene Expression
Fundamental Properties of Genes Replication enzymes 1 RNA polymerases Positive and negative regulation: lac
Nucleic acids 1 Replication enzymes 2 General txn Iinitiation Factors Measuring binding constants, Prot-DNA
Nucleic acids 2 Repln origins and terminators Promoters Lessons from Kb and kf
Recomb DNA, PCR 1 Topological issues in replication Elongation, termination of txn Molecular switch/decision in lambda
Recomb DNA 2 Mutation RNA processing Regulation after initiation
Eukaryotic gene structure Repair
Error-prone repair		 RNA splicing Silencers and enhancers
Genomes 1 Recombination: Models from genetics Genetic code Domains of activators
Genomes 2 Recombination: Enzymology
Figure with pathways of recombination		 Translation components Activation of transcription
Chromosomes Transposition Translation mechanisms Active and inactive chromatin
Nucleosome remodeling
Active chrom +Nucl. Remodel_short

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Useful Links
Rasmol Home Page : http://www.umass.edu/microbio/rasmol/
Nucleic Acid Structures (Lecture 5) :  http://chemistry.g su.edu/glactone/PDB/DNA_RNA/dna.html
Script for DNA structure movie (Lecture 4) : http://www.umass.ed u/microbio/rasmol/scrip_mz.htm#bil