BMB/MICRB 252:  MOLECULAR AND CELL BIOLOGY II

Spring 2004 - Mon Wed Fri 10:10-11:00   102 Thomas

Dr. Frank Pugh

(lec 1-22)

Dr. Pamela Mitchell

(lec 23-46)

office: 452 N. Frear

office: 332 S. Frear

phone: 863-8252

phone: 863-5802

email: bfp2@psu.edu

email: pjm23@psu.edu

office hours: Mon.11:00-1:00  or by appointment

office hours: Fri. 1:00-3:00 or by appointment

Notes for lec 1-22 (PDF)
 

lec

date

TOPIC

READING: chpt(pgs)

Dr. Pugh's lectures

1

Jan. 12

 Principles of cell communication

 15 (831-841)

2

Jan. 14

 Principles of cell communication

 15 (842-852)

3

Jan. 16

 G-protein-linked receptors

 15 (852-871)

4

Jan. 19

 G-protein-linked receptors

 15 (852-871)

5

Jan. 21

 Enzyme-linked receptors

 15 (871-889)

6

Jan. 23

 Enzyme-linked receptors

 15 (871-889)

7

Jan. 26

 Enzyme-linked receptors

 15 (871-889)

8

Jan. 28

 Signaling via proteolysis

 15 (893-899)

9

Jan. 30

 Signaling via proteolysis

 15 (893-899)

10

Feb. 2

Review

 

11

Feb. 4

Exam1

 Chapter 15

12

Feb. 6

Cytoskeleton assembly

16 (907-929)

13

Feb. 9

Cytoskeleton regulation

16  (929-948)

14

Feb. 11

Molecular motors

16 (949-968)

15

Feb. 13

Cell junctions

19 (1066-1080)

16

Feb. 16

Cell-cell adhesion

19 (1080-1090)

17

Feb. 18

Extracellular matrix and Integrins

19 (1090-1118)

18

Feb. 20

The cell cycle

17 (983-990)

19

Feb. 23

Control of the cell cycle

17 (990-1010)

20

Feb. 25

Programmed cell death

17 (1010-1014)

21

Feb. 27

Review

 

22

Mar. 1

Exam 2

 Chapters 16, 17, 19

Dr. Mitchell's lectures

23

Mar. 3

Mitosis, part 1

18 (1027-1045)

24

Mar. 5

Mitosis, part 2

18 (1045-1056)

 

 

Spring Break J

 

25

Mar. 15

Meiosis, part 1

20 (1127-1139)

26

Mar. 17

PGCs, sex determination, gametogenesis (meiosis, part 2)

20 (1139-1150)

27

Mar. 19

Development of multicellular organisms: intro

21 (1157-1164)

28

Mar. 22

Generating positional information in the embryo

21 (1164-1174

29

Mar. 24

Body plan genes, Drosophila as model

21 (1177-1185)

30

Mar. 26

Body plan genes, Drosophila as model

21 (1185-1190)

31

Mar. 29

Hox genes and birth of Evo Devo

21 (1190-1204)

32

Mar. 31

Building the nervous system

21 (1227-1241)

33

Apr. 2

Review

 

34

Apr. 5

Exam 3

Chpts 18, 20, 21

35

Apr. 7

Neurogenesis & neural stem cells

21 (1204-1210)

36

Apr. 9

Epithelial stem cells

22 (1259-1272)

37

Apr. 12

Endothelial cells & angiogenesis, hemopoiesis

22 (1279-1289)

38

Apr. 14

Hemopoiesis, part 2

22 (1289-1296)

39

Apr. 16

Myo-, adipo-, chondro-, & osteogenesis

22 (1296-1308)

40

Apr. 19

Cancer: microevolution of bad citizen cells

23 (1313-1326)

41

Apr. 21

Carcinogens & tumor promotion

23 (1326-1336)

42

Apr. 23

Cancer-critical genes: Ras, Rb, p53 and more

23 (1337-1345)

43

Apr. 26

Tumor progression, metastasis

23 (1346-1355)

44

Apr. 28

Cancer treatments: present and future

23 (1356-1361)

45

Apr. 30

Review

 

46

 May 7

Exam 4 - 12:20-2:10 pm in 010 Sparks

 Chapters 21, 22, 23

Required textbook: Alberts, et al., Molecular Biology of the Cell, fourth edition. You should complete the reading assignment before classso that you are familiar with the lecture material.  This should aid you in following each lecture.

Lecture notes: Overhead notes that are used in lectures and any figures not in the Alberts text will be posted before class. You are strongly encouraged to bring these lecture notes to class.  Links to the notes that have been posted are made by clicking on the lecture number in the schedule posted above.

Exams: Each exam will consist of 33 multiple choice questions worth 3 points each.  You will be asked to present your student I.D. when you submit your exams.  Scores will be reported by email to your student account directly from University Testing Services.

Grades: The following table gives approximate assignments for final grades. This scale is based on an overall class mean of 75% orhigher. If the class mean is lower, the scale will be adjusted downward. It will not be adjusted upward. So for example, if you earn a 90% or higher you are guaranteed an A or A-.
 

GRADE:

PERCENTAGE:

A and A-

90%-100%

B+, B and B-

75%-90%

C+ and C

60%-75%

D

50%-60%

F

lower than 50%

Missed exams: Make up exams are either all essay questions or a mixture of essay and short answer questions (instructor's discretion) and mustbe taken prior to the next exam, or you will receive a zero. Whenever possible,notify the instructor prior to the exam. Exams should only be missed for a family emergency, accident, or serious illness.

No extra credit work will be accepted.  No exams will be dropped.

Academic integrity: The students and instructors are bound bythe rules and procedures on academic integrity set by the Eberly College of Science Academic Integrity Committee. A complete listing of these policies canbe foundat the following web site: http://www.science.psu.edu/academic/Integrity/index.html.

It is the student's responsibility to know and abide by these policies. Failure to do so may result in sanctions or expulsion.