Publications by Zhi-Chun Lai

2007

Wei, X., T. Shimizu, and Z.-C. Lai.  Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila.  EMBO J. 26:1772-1781.

Zhao, B., X. Wei, W. Li, R. S. Udan, Q. Yang, J. Kim, J. Xie, T. Ikenoue, J. Yu, L. Li, P. Zheng, K. Ye, A. Chinnaiyan, G. Halder, Z.-C. Lai, and K.-L. Guan.  Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.  Genes & Dev. 21:2747-2761.

2006

Yuan, Y., Z.-Y. Zhu, Z.-C. Lai, and W.-X. Zhang.  Progress on breast cancer metastasis suppressor 1 (BRMS1).  Hereditas 28:1-8.

2005

Lai, Z.-C., X. Wei, T. Shimizu, E. Ramos, M. Rohrbaugh, N. Nikolaidis, L.-L. Ho, and Y. Li. Control of cell proliferation and apoptosis by Mob as tumor suppressor, Mats. Cell 120:675-685.

2003

Ramos, E., M. Price, M. Rohrbaugh, and Z.-C. Lai. Identifying functional cis-acting regulatory modules of the yan gene in Drosophila melanogaster. Dev. Genes Evol. 213:83-89.

Li, Y., M. Fetchko, Z.-C. Lai, and N.E. Baker. Scabrous and Gp150 are endosomal proteins that regulate Notch activity. Development 130:2819-2827.

2002

Rohrbaugh, M., E. Ramos, D. Nguyen, M. Price, Y. Wen, and Z.-C. Lai. Notch activation of yan expression is antagonized by RTK/pointed signaling in the Drosophila eye. Curr. Biol. 12:576-581.

Fetchko, M., W. Huang, Y. Li, and Z.-C. Lai. Drosophila Gp150 is required for early ommatidial development through modulation of notch signaling. EMBO J. 21:1074-1083.

2000

Nguyen, D., M. Rohrbaugh, and Z.-C. Lai. The Drosophila Homolog of Onecut Homeodomain Proteins is a Neural-specific Transcription Activator with a Potential Role in Regulating Neural Differentiation. Mech. Dev. 97:55-70.

Wen, Y., D. Nguyen, Y. Li, and Z.-C. Lai. The N-terminal BTB/POZ Domain and C-terminal Sequences are Essential for Tramtrack69 to Specify Cell Fate in the Developing Drosophila Eye. Genetics 156:195-203.

Dhulkotia, D., D. Nguyen, and Z.-C. Lai. Evolutionary Conservation of a Leucine-rich Repeat Transmembrane Protein Gp150 in Drosophila and Bombyx. Dev. Genes Evol. 210:145-150.

1999

Lai, Z.-C. and Y. Li. Tramtrack69 is Positively and Autonomously Required for Drosophila Photoreceptor Development. Genetics 152:299-305.

Price, M. and Z.-C. Lai. The yan Gene is Highly Conserved in Drosophila and Its Expression Suggests a Complex Role Throughout Development. Dev. Genes Evol. 209:207-217.

1998

van Huizen, R., K. Miller, D.-M. Chen, Y. Li, Z.-C. Lai, R.W. Raab, W.S. Stark, R.D. Shortridge, and M. Li. Two Distinctly Positioned PDZ Domains Mediate Multivalent INAD-phospholipae C Interactions Essential for G Protein-coupled Signaling. EMBO J. 17:2285-2297.

1997

Balczarek, K.A., Z.-C. Lai, and S. Kumar. Evolution and Functional Diversification of the Paired Box (Pax) DNA-binding Domains. Mol. Biol. Evol. 14:829-842.

Lai, Z.-C., M. Fetchko, and Y. Li. Repression of Drosophila Photoreceptor Cell Fate Through Cooperative Action of Two Transcriptional Repressors Yan and Tramtrack. Genetics 147-1131 1137.

Li, S., Y. Li, R.W. Carthew, and Z.-C. Lai. Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack. Cell 90:469-478.

1996

Kumar, S., K.A. Balczarek, and Z.-C. Lai. Evolution of the hedgehog Gene Family. Genetics 142:965-972.

Lai, Z.-C., S.D. Harrison, F. Karim, Y. Li, and G. M. Rubin. Loss of tramtrack Gene Activity results in Ectopic R7 Cell Formation, Even in a sina Mutant Background. Proc. Natl. Acad. Sci. USA 93:5025-5030.

1995

Treisman, J.E., Z.-C. Lai, and G.M. Rubin. Shortsighted Acts in the Decapentaplegic Pathway in Drosophila Eye Development and has Homology to a Mouse TGF-beta-responsive. Gene Dev. l2l:2835-2845.