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Publications by Craig E. Cameron

2007

Marcotte, L. L., A. B. Wass, D. W. Gohara, H. B. Pathak, J. J. Arnold, D. J. Filman, C. E. Cameron, and J. M. Hogle. Crystal structure of poliovirus 3CD: Virally-encoded protease and precursor to the RNA-dependent RNA polymerase. J. Virol. 81:3583-3596.

Castro, C., E. Smidansky, K. R. Maksimchuk, J. J. Arnold, V. S. Korneeva, M. Gotte, W. Konigsberg, and C. E. Cameron. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc. Natl. Acad. Sci USA 104:4267-4272.

Pathak H. B., J. J. Arnold, P. N. Wiegand, M. R. Hargittai, and C. E. Cameron. Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. J. Biol. Chem. 282:16202-16213.

Korneeva, V. S. and C. E. Cameron. Structure-function relationships of the viral RNA-dependent RNA polymerase: Fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J. Biol. Chem. 282:16135-16145.

Harki, D. A., J. D. Graci, J. P. Edathil, C. Castro, C. E. Cameron, and B. R. Peterson. Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. ChemBioChem 8:1359-1362.

Graci, J. D., D. A. Harki, V. S. Korneeva, J. P. Edathil, K. Too, D. Franco, E. D. Smidansky, A. V. Paul, B. R. Peterson, D. M. Brown, D. Loakes, and C. E. Cameron. Lethal mutagenesis of poliovirus caused by poliovirus-dependent and –independent incorporation of a mutagenic pyrimidine analog. J. Virol. 81:11256-11266.

Shen, M., Q. Wang, Y. Yang, H. B. Pathak, J. J. Arnold, C. Castro, S. M. Lemon, and C. E. Cameron. Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex. J. Virol. 81:12485-12495.

Nallagatla, S. R., J. Hwang, R. Toroney, X. Zheng, C. E. Cameron, and P. C. Bevilacqua. 5’-Triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science 318:1455-1458.

2006

Mackintosh, S. G., J. Z. Lu, J. B. Jordan, M. K. Harrison, B. Sikora, S. D. Sharma, C. E. Cameron, K. D. Raney, and J. Sakon. Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J. Biol. Chem. 281:3528-3535.

Arnold, J. J., A. Bernal, U. Uche, D. E. Sterner, T. R. Butt, C. E. Cameron, and M. R. Mattern. Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. Anal. Biochem. 350:214-221.

Vignuzzi, M., J. K. Stone, J. J. Arnold, C. E. Cameron, and R. Andino. Genomic diversity in a viral population determines fitness, tissue tropism and pathogenesis. Nature 439:344-348.

van Ooij, M. J. M., D. A. Vogt, A. Paul, C. Castro, J. Kuijpers, F. J. M. van Kuppeveld, C. E. Cameron, E. Wimmer, R. Andino, and W. J. G. Melchers. Structural and functional characterization of the coxsackievirus B3 CRE(2C): Role of CRE(2C) in negative and positive strand RNA synthesis. J. Gen. Virol. 87:103-113.

Takhampunya, R., S. Ubol, H.-S. Houng, C. E. Cameron, and R. Padmanabhan. Inhibition of Dengue viral replication by mycophenolic acid and ribavirin. J. Gen. Virol. 87:1947-1952.

Lanzi, G., J. R. de Miranda, M. B. Boniotti, C. E. Cameron, A. Lavazza, L. Capucci, S. M. Camazine, and C. Rossi. Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J. Virol. 80:4998-5009.

D’Abramo, C. M., J. Deval, C. E. Cameron, L. Cellai, and M. Gotte. Control of template positioning during de novo initiation of RNA synthesis by bovine viral diarrhea virus NS5B polymerase. J. Biol. Chem. 281:24991-24998.

Harki, D. A., J. D. Graci, J. E. Galarrage, W. J. Chain, C. E. Cameron, and B. R. Peterson. Synthesis and antiviral activity of 5-substituted cytidine analogues: Identification of a potent inhibitor of viral RNA-dependent RNA polymerases. J. Med. Chem. 49:6166-6169.

Graci, J. D. and C. E. Cameron. Mechanisms of action of ribavirin against distinct viruses. Rev. Med. Virol. 16:37-48.

2005

Tackett, A. J., Y. Chen, C. E. Cameron, and K. D. Raney. Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro. J. Biol. Chem. 280:10797-10806.

Castro, C., J. J. Arnold, and C. E. Cameron. Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res. 107:141-149.

Belliot, G., S. V. Sosnovtsev, K.-O. Chang, V. Babu, U. Uche, J. Arnold, C. E. Cameron, and K. Green. The norovirus proteinase-polymerase and polymerase are both active forms of the RNA-dependent RNA polymerase. J. Virol. 79:2393-2403.

Franco, D., H. B. Pathak, C. E. Cameron, B. Rombaut, E. Wimmer, and A. V. Paul. Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. J. Virol. 79:6358-6367.

Arnold, J. J., M. Vignuzzi, J. Stone, R. Andino, and C. E. Cameron. Remote-site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J. Biol. Chem. 280:25706-25716.

Huang, L., J. Hwang, S. D. Sharma, M. R. Hargittai, Y. Chen, S. Reynolds, J. J. Arnold, K. D. Raney, and C. E. Cameron. Hepatitis C virus non-structural protein 5A (NS5A) is a RNA-binding protein. J. Biol. Chem. 280:36417-36428.

Franco, D., H. B. Pathak, C. E. Cameron, B. Rombaut, E. Wimmer, and A. V. Paul. Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. Virol. J. 2:86.

Graci, J. D. and C. E. Cameron. Lethal mutagenesis: Exploiting error-prone replication of riboviruses for antiviral therapy. In: Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats. (P. F. Torrence, ed.), pp. 203-220, John Wiley & Sons, Hoboken, NJ.

2004

Arnold, J.J. and C.E. Cameron. Poliovirus RNA-dependent RNA polymerase (3D^pol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg²⁺. Biochemistry 43:5126-5137.

Arnold, J.J., D.W. Gohara, and C.E. Cameron. Poliovirus RNA-dependent RNA polymerase (3D^pol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn²⁺. Biochemistry 43:5138-5148.

Gohara, D.W., J.J. Arnold, and C.E. Cameron. Poliovirus RNA-dependent RNA polymerase (3D^pol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry 43:5149-5158.

de Miranda, J.R., M. Drebot, S. Tyler, M. Shen, C.E. Cameron, D.B. Stoltz, and S.M. Camazine. Complete nucleotide sequence of Kashmir bee virus and comparison with acute bee paralysis virus. J. Gen. Virol. 85:2263-2270.

Huang, L., E.V. Sineva, M.R.S. Hargittai, S.D. Sharma, M. Suthar, K.D. Raney, and C.E. Cameron. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr. Purif. 37:144-153.

Graci, J.D. and C.E. Cameron. Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir. Chem. Chemother. 15:1-13.

Freistadt, M.S., G.D. Meades, and C.E. Cameron. Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance? Drug Resist. Update 7:19-24.

2003

Crotty, S., D. Gohara, D.K. Gilligan, S. Karelsky, C.E. Cameron, and R. Andino. Manganese dependent polioviruses with mutations in the highly conserved NTP binding site of the polymerase. J. Virol. 77:5378-5388.

Huang, L., J. Gledhill, and C.E. Cameron. The RNA-dependent RNA polymerase. In: Gene Silencing. (G. Hannon, ed.), pp. 175-203, Cold Spring Harbor Press, Cold Spring Harbor, NY.

2002

Morris, P.D., A.K. Byrd, A.J. Tackett, C.E. Cameron, and K.D. Raney. NS3 helicase displaces streptavidin from 5´-biotinylated oligonucleotides but not from 3´-biotinylated oligonucleotides: Evidence for a directional bias in translocation on single-stranded DNA. Biochemistry. 41:2372-2378.

Harki, D.A., J.D. Graci, V.S. Korneeva, S.K.B. Ghosh, Z. Hong, C. E. Cameron, and B.R. Peterson. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-β-D-ribofuranosyl-3-nitropyrrole. Biochemistry. 41:9026-9033.

Green, K.Y., A. Mory, M.H. Fogg, A. Weisberg, G. Belliot, M. Wagner, T. Mitra, E. Ehrenfeld, C.E. Cameron, and S.V. Sosnovtsev. Isolation of enzymatically-active replication complexes from feline calicivirus-infected cells. J. Virol. 76:8582-8595.

Pathak, H.P., S.K.B. Ghosh, A.W. Roberts, S.D. Sharma, J.D. Yoder, J.J. Arnold, D.W. Gohara, D.J. Barton, A.V. Paul, and C.E. Cameron. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol): A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J. Biol. Chem. 277:31551-31562.

Gorbalenya, A.E., F.M. Pringle, J.-L. Zeddam, B.T. Luke, C.E. Cameron, J. Kalmakoff, T. Hanzlik, K. Gordon, and V.K. Ward. The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage. J. Mol. Biol. 324:47-62.

Cameron, C. E., D.W. Gohara, and J.J. Arnold. Poliovirus RNA-dependent RNA polymerase (3Dpol): Structure, function and mechanism. In: Molecular Biology of Picornaviruses. (B. L. Semler and E. Wimmer, eds.), pp. 255-267, ASM Press, Washington, D.C.

Graci, J.D., and C. E. Cameron. Quasispecies, error catastrophe and the antiviral activity of ribavirin. Virology. 298:175-180.

Hong, Z., and C. E. Cameron. Pleiotropic mechanisms of ribavirin antiviral activities. Prog. Drug Res. 59:41-69.

Crotty, S., C. Cameron, and R. Andino. Ribavirin's antiviral mechanism of action: lethal mutagenesis? J. Mol. Med. 80:86-95.

2001

Cameron, C.E., and C. Castro. The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA ploymerase. Curr. Opin. Infect. Dis. 14:757-764.

Maag, D., C. Castro, Z. Hong, and C.E. Cameron. Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276:46094-46098.

Hong, Z., C.E. Cameron, M.P. Walker, C. Castro, N. Yao, J.Y.N. Lau, and W. Zhong. A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology. 285:6-11.

Crotty, S., C.E. Cameron, and R. Andino. RNA virus error catastrophe: Direct molecular test by using ribavirin. Proc. Natl. Acad. Sci. USA 98:6895-6900.

Wei, L., J.S. Huhn, A. Mory, H.B. Pathak, S.V. Sosnovtsev, K.Y. Green, and C.E. Cameron. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase. J. Virol. 75:1211-1219.

Tackett, A.J., L. Wei, C.E. Cameron, and K.D. Raney. Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex. Nucleic Acids Res. 29:565-572.

2000

Arnold, J.J. and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase (3D^pol): Assembly of Stable, Elongation-competent Complexes by Using a Symmetrical Primer/Template Substrate (sym/sub). J. Biol. Chem. 275:5329-5336.

Gohara, D.W., S. Crotty, J.J. Arnold, J.D. Yoder, R. Andino, and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase (3D^pol): Structural, Biochemical and Biological Analysis of Conserved Structural Motifs A and B. J. Biol. Chem. 275:25523-25532.

Zhong, W., E. Ferrari, C. Lesburg, D. Maag, S.K.B. Ghosh, C.E. Cameron, J.Y.N. Lau, and Z. Hong. Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase. J. Virol. 74:9134-9143.

Crotty, S., D. Maag, J.J. Arnold, W. Zhong, J.N.Y. Lau, Z. Hong, R. Andino, and C.E. Cameron. The Broad-spectrum Antiviral Ribonucleoside, Ribavirin, is a RNA Virus Mutagen. Nature Medicine 6:1375-1379.

1999

Arnold, J.J. and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase, 3D^pol is Sufficient for Template Switching in vitro. J. Biol. Chem. 274:2706-2716.

Arnold, J.J., S.K.B. Ghosh, P.C. Bevilacqua, and C.E. Cameron. A Rapid and Efficient Method for Single-nucleotide Resolution of RNA Strands in the Presence of Their RNA Complements. BioTechniques 27:450-456.

Arnold, J.J., S.K.B. Ghosh, and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase (3D^pol): Divalent Cation Modulation of Primer, Template and Nucleotide Selection. J. Biol. Chem. 274:37060-37069.

Cameron, C.E. A Review of: Hepatitis C Protocols. In: Methods in Molecular Medicine, Vol. 19, (J.Y.-N. Lau, ed.), Q. Rev. Bio. 74:509-510.

Gohara, D.W., C.S. Ha, S.K.B. Ghosh, J.J. Arnold, T.J. Wisniewski, and C.E. Cameron. Production of "Authentic" Poliovirus RNA-dependent RNA Polymerase (3D^pol) by Ubiquitin-Protease-mediated Cleavage in Escherichia coli. Protein Expres. Purif. 17:128-138.

1997

Cameron, C.E., M. Ghosh, S.F.J. LeGrice, and S.J. Benkovic. Mutations in HIV Reverse Transcriptase which Alter RNAse H Activity and Decrease Strand Transfer Efficiency are Suppressed by HIV Nucleocapsid Protein. Proc. Natl. Acad. Sci. USA 94:6700-6705.

Cameron, C.E. and S.J. Benkovic. Evidence for a Functional Role of the Dynamics of Glycine-121 of Escherichia coli Dihydrofolate Reductase Obtained from Kinetic Analysis of a Site Directed Mutant. Biochemistry 36:15792-15800.

Shao, H., M.D. Robek, D.S. Threadgill, L.S. Mankowski, C.E. Cameron, F.J. Fuller, and S.J. Payne. Characterization and Mutational Studies of Equine Infectious Anemia Virus dUTPase. Biochim. Biophy. Acta. 1339:181-191.


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About Us Faculty Facilities Seminars Publications News and Events Outreach Links	Publications by Craig E. Cameron 2007 Marcotte, L. L., A. B. Wass, D. W. Gohara, H. B. Pathak, J. J. Arnold, D. J. Filman, C. E. Cameron, and J. M. Hogle. Crystal structure of poliovirus 3CD: Virally-encoded protease and precursor to the RNA-dependent RNA polymerase. J. Virol. 81:3583-3596. Castro, C., E. Smidansky, K. R. Maksimchuk, J. J. Arnold, V. S. Korneeva, M. Gotte, W. Konigsberg, and C. E. Cameron. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc. Natl. Acad. Sci USA 104:4267-4272. Pathak H. B., J. J. Arnold, P. N. Wiegand, M. R. Hargittai, and C. E. Cameron. Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. J. Biol. Chem. 282:16202-16213. Korneeva, V. S. and C. E. Cameron. Structure-function relationships of the viral RNA-dependent RNA polymerase: Fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J. Biol. Chem. 282:16135-16145. Harki, D. A., J. D. Graci, J. P. Edathil, C. Castro, C. E. Cameron, and B. R. Peterson. Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. ChemBioChem 8:1359-1362. Graci, J. D., D. A. Harki, V. S. Korneeva, J. P. Edathil, K. Too, D. Franco, E. D. Smidansky, A. V. Paul, B. R. Peterson, D. M. Brown, D. Loakes, and C. E. Cameron. Lethal mutagenesis of poliovirus caused by poliovirus-dependent and –independent incorporation of a mutagenic pyrimidine analog. J. Virol. 81:11256-11266. Shen, M., Q. Wang, Y. Yang, H. B. Pathak, J. J. Arnold, C. Castro, S. M. Lemon, and C. E. Cameron. Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex. J. Virol. 81:12485-12495. Nallagatla, S. R., J. Hwang, R. Toroney, X. Zheng, C. E. Cameron, and P. C. Bevilacqua. 5’-Triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science 318:1455-1458. 2006 Mackintosh, S. G., J. Z. Lu, J. B. Jordan, M. K. Harrison, B. Sikora, S. D. Sharma, C. E. Cameron, K. D. Raney, and J. Sakon. Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J. Biol. Chem. 281:3528-3535. Arnold, J. J., A. Bernal, U. Uche, D. E. Sterner, T. R. Butt, C. E. Cameron, and M. R. Mattern. Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. Anal. Biochem. 350:214-221. Vignuzzi, M., J. K. Stone, J. J. Arnold, C. E. Cameron, and R. Andino. Genomic diversity in a viral population determines fitness, tissue tropism and pathogenesis. Nature 439:344-348. van Ooij, M. J. M., D. A. Vogt, A. Paul, C. Castro, J. Kuijpers, F. J. M. van Kuppeveld, C. E. Cameron, E. Wimmer, R. Andino, and W. J. G. Melchers. Structural and functional characterization of the coxsackievirus B3 CRE(2C): Role of CRE(2C) in negative and positive strand RNA synthesis. J. Gen. Virol. 87:103-113. Takhampunya, R., S. Ubol, H.-S. Houng, C. E. Cameron, and R. Padmanabhan. Inhibition of Dengue viral replication by mycophenolic acid and ribavirin. J. Gen. Virol. 87:1947-1952. Lanzi, G., J. R. de Miranda, M. B. Boniotti, C. E. Cameron, A. Lavazza, L. Capucci, S. M. Camazine, and C. Rossi. Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J. Virol. 80:4998-5009. D’Abramo, C. M., J. Deval, C. E. Cameron, L. Cellai, and M. Gotte. Control of template positioning during de novo initiation of RNA synthesis by bovine viral diarrhea virus NS5B polymerase. J. Biol. Chem. 281:24991-24998. Harki, D. A., J. D. Graci, J. E. Galarrage, W. J. Chain, C. E. Cameron, and B. R. Peterson. Synthesis and antiviral activity of 5-substituted cytidine analogues: Identification of a potent inhibitor of viral RNA-dependent RNA polymerases. J. Med. Chem. 49:6166-6169. Graci, J. D. and C. E. Cameron. Mechanisms of action of ribavirin against distinct viruses. Rev. Med. Virol. 16:37-48. 2005 Tackett, A. J., Y. Chen, C. E. Cameron, and K. D. Raney. Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro. J. Biol. Chem. 280:10797-10806. Castro, C., J. J. Arnold, and C. E. Cameron. Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res. 107:141-149. Belliot, G., S. V. Sosnovtsev, K.-O. Chang, V. Babu, U. Uche, J. Arnold, C. E. Cameron, and K. Green. The norovirus proteinase-polymerase and polymerase are both active forms of the RNA-dependent RNA polymerase. J. Virol. 79:2393-2403. Franco, D., H. B. Pathak, C. E. Cameron, B. Rombaut, E. Wimmer, and A. V. Paul. Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. J. Virol. 79:6358-6367. Arnold, J. J., M. Vignuzzi, J. Stone, R. Andino, and C. E. Cameron. Remote-site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J. Biol. Chem. 280:25706-25716. Huang, L., J. Hwang, S. D. Sharma, M. R. Hargittai, Y. Chen, S. Reynolds, J. J. Arnold, K. D. Raney, and C. E. Cameron. Hepatitis C virus non-structural protein 5A (NS5A) is a RNA-binding protein. J. Biol. Chem. 280:36417-36428. Franco, D., H. B. Pathak, C. E. Cameron, B. Rombaut, E. Wimmer, and A. V. Paul. Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. Virol. J. 2:86. Graci, J. D. and C. E. Cameron. Lethal mutagenesis: Exploiting error-prone replication of riboviruses for antiviral therapy. In: Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats. (P. F. Torrence, ed.), pp. 203-220, John Wiley & Sons, Hoboken, NJ. 2004 Arnold, J.J. and C.E. Cameron. Poliovirus RNA-dependent RNA polymerase (3D^pol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg²⁺. Biochemistry 43:5126-5137. Arnold, J.J., D.W. Gohara, and C.E. Cameron. Poliovirus RNA-dependent RNA polymerase (3D^pol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn²⁺. Biochemistry 43:5138-5148. Gohara, D.W., J.J. Arnold, and C.E. Cameron. Poliovirus RNA-dependent RNA polymerase (3D^pol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry 43:5149-5158. de Miranda, J.R., M. Drebot, S. Tyler, M. Shen, C.E. Cameron, D.B. Stoltz, and S.M. Camazine. Complete nucleotide sequence of Kashmir bee virus and comparison with acute bee paralysis virus. J. Gen. Virol. 85:2263-2270. Huang, L., E.V. Sineva, M.R.S. Hargittai, S.D. Sharma, M. Suthar, K.D. Raney, and C.E. Cameron. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr. Purif. 37:144-153. Graci, J.D. and C.E. Cameron. Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir. Chem. Chemother. 15:1-13. Freistadt, M.S., G.D. Meades, and C.E. Cameron. Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance? Drug Resist. Update 7:19-24. 2003 Crotty, S., D. Gohara, D.K. Gilligan, S. Karelsky, C.E. Cameron, and R. Andino. Manganese dependent polioviruses with mutations in the highly conserved NTP binding site of the polymerase. J. Virol. 77:5378-5388. Huang, L., J. Gledhill, and C.E. Cameron. The RNA-dependent RNA polymerase. In: Gene Silencing. (G. Hannon, ed.), pp. 175-203, Cold Spring Harbor Press, Cold Spring Harbor, NY. 2002 Morris, P.D., A.K. Byrd, A.J. Tackett, C.E. Cameron, and K.D. Raney. NS3 helicase displaces streptavidin from 5´-biotinylated oligonucleotides but not from 3´-biotinylated oligonucleotides: Evidence for a directional bias in translocation on single-stranded DNA. Biochemistry. 41:2372-2378. Harki, D.A., J.D. Graci, V.S. Korneeva, S.K.B. Ghosh, Z. Hong, C. E. Cameron, and B.R. Peterson. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-β-D-ribofuranosyl-3-nitropyrrole. Biochemistry. 41:9026-9033. Green, K.Y., A. Mory, M.H. Fogg, A. Weisberg, G. Belliot, M. Wagner, T. Mitra, E. Ehrenfeld, C.E. Cameron, and S.V. Sosnovtsev. Isolation of enzymatically-active replication complexes from feline calicivirus-infected cells. J. Virol. 76:8582-8595. Pathak, H.P., S.K.B. Ghosh, A.W. Roberts, S.D. Sharma, J.D. Yoder, J.J. Arnold, D.W. Gohara, D.J. Barton, A.V. Paul, and C.E. Cameron. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol): A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J. Biol. Chem. 277:31551-31562. Gorbalenya, A.E., F.M. Pringle, J.-L. Zeddam, B.T. Luke, C.E. Cameron, J. Kalmakoff, T. Hanzlik, K. Gordon, and V.K. Ward. The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage. J. Mol. Biol. 324:47-62. Cameron, C. E., D.W. Gohara, and J.J. Arnold. Poliovirus RNA-dependent RNA polymerase (3Dpol): Structure, function and mechanism. In: Molecular Biology of Picornaviruses. (B. L. Semler and E. Wimmer, eds.), pp. 255-267, ASM Press, Washington, D.C. Graci, J.D., and C. E. Cameron. Quasispecies, error catastrophe and the antiviral activity of ribavirin. Virology. 298:175-180. Hong, Z., and C. E. Cameron. Pleiotropic mechanisms of ribavirin antiviral activities. Prog. Drug Res. 59:41-69. Crotty, S., C. Cameron, and R. Andino. Ribavirin's antiviral mechanism of action: lethal mutagenesis? J. Mol. Med. 80:86-95. 2001 Cameron, C.E., and C. Castro. The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA ploymerase. Curr. Opin. Infect. Dis. 14:757-764. Maag, D., C. Castro, Z. Hong, and C.E. Cameron. Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276:46094-46098. Hong, Z., C.E. Cameron, M.P. Walker, C. Castro, N. Yao, J.Y.N. Lau, and W. Zhong. A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology. 285:6-11. Crotty, S., C.E. Cameron, and R. Andino. RNA virus error catastrophe: Direct molecular test by using ribavirin. Proc. Natl. Acad. Sci. USA 98:6895-6900. Wei, L., J.S. Huhn, A. Mory, H.B. Pathak, S.V. Sosnovtsev, K.Y. Green, and C.E. Cameron. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase. J. Virol. 75:1211-1219. Tackett, A.J., L. Wei, C.E. Cameron, and K.D. Raney. Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex. Nucleic Acids Res. 29:565-572. 2000 Arnold, J.J. and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase (3D^pol): Assembly of Stable, Elongation-competent Complexes by Using a Symmetrical Primer/Template Substrate (sym/sub). J. Biol. Chem. 275:5329-5336. Gohara, D.W., S. Crotty, J.J. Arnold, J.D. Yoder, R. Andino, and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase (3D^pol): Structural, Biochemical and Biological Analysis of Conserved Structural Motifs A and B. J. Biol. Chem. 275:25523-25532. Zhong, W., E. Ferrari, C. Lesburg, D. Maag, S.K.B. Ghosh, C.E. Cameron, J.Y.N. Lau, and Z. Hong. Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase. J. Virol. 74:9134-9143. Crotty, S., D. Maag, J.J. Arnold, W. Zhong, J.N.Y. Lau, Z. Hong, R. Andino, and C.E. Cameron. The Broad-spectrum Antiviral Ribonucleoside, Ribavirin, is a RNA Virus Mutagen. Nature Medicine 6:1375-1379. 1999 Arnold, J.J. and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase, 3D^pol is Sufficient for Template Switching in vitro. J. Biol. Chem. 274:2706-2716. Arnold, J.J., S.K.B. Ghosh, P.C. Bevilacqua, and C.E. Cameron. A Rapid and Efficient Method for Single-nucleotide Resolution of RNA Strands in the Presence of Their RNA Complements. BioTechniques 27:450-456. Arnold, J.J., S.K.B. Ghosh, and C.E. Cameron. Poliovirus RNA-dependent RNA Polymerase (3D^pol): Divalent Cation Modulation of Primer, Template and Nucleotide Selection. J. Biol. Chem. 274:37060-37069. Cameron, C.E. A Review of: Hepatitis C Protocols. In: Methods in Molecular Medicine, Vol. 19, (J.Y.-N. Lau, ed.), Q. Rev. Bio. 74:509-510. Gohara, D.W., C.S. Ha, S.K.B. Ghosh, J.J. Arnold, T.J. Wisniewski, and C.E. Cameron. Production of "Authentic" Poliovirus RNA-dependent RNA Polymerase (3D^pol) by Ubiquitin-Protease-mediated Cleavage in Escherichia coli. Protein Expres. Purif. 17:128-138. 1997 Cameron, C.E., M. Ghosh, S.F.J. LeGrice, and S.J. Benkovic. Mutations in HIV Reverse Transcriptase which Alter RNAse H Activity and Decrease Strand Transfer Efficiency are Suppressed by HIV Nucleocapsid Protein. Proc. Natl. Acad. Sci. USA 94:6700-6705. Cameron, C.E. and S.J. Benkovic. Evidence for a Functional Role of the Dynamics of Glycine-121 of Escherichia coli Dihydrofolate Reductase Obtained from Kinetic Analysis of a Site Directed Mutant. Biochemistry 36:15792-15800. Shao, H., M.D. Robek, D.S. Threadgill, L.S. Mankowski, C.E. Cameron, F.J. Fuller, and S.J. Payne. Characterization and Mutational Studies of Equine Infectious Anemia Virus dUTPase. Biochim. Biophy. Acta. 1339:181-191.
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